Jamie-Lynn Sigler to Guest on "Grey's Anatomy"

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Jamie-Lynn Sigler to Play Doctor with MS on "Grey’s Anatomy"
by Nellie Andreeva
December 11, 2025


Jamie-Lynn Sigler (The Sopranos, Big Sky) has landed a guest-starring role on ABC's hit medical drama "Grey’s Anatomy".

Appearing in the Jan. 15 episode, “Heavy on Me,” Sigler will play Dr. Laura Kaplan, a urologist living with Multiple Sclerosis, who visits Grey Sloan at the request of Catherine Fox (Debbie Allen) and offers Richard (James Pickens Jr.) a unique perspective on his case.

The role was created for Sigler, who has lived with MS for more than two decades and marks her return to television after a three-year break. I hear it was important to the show’s producers and to Sigler that the character is not defined by their affliction and has a full life and a career.

https://deadline.com/2025/12/jamie-l...ms-1236644008/

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Jamie-Lynn Sigler was "extremely emotional" in return to acting on Grey's