"St. Denis Medical" Season 2 Guest Stars Announced

[JamesG]

"St. Denis Medical" Admits Kristen Schaal and More
by Andy Swift
October 3, 2025


NBC’s "St. Denis Medical" has announced seven guest stars for its upcoming second season, TVLine has learned:


- Kristen Schaal (Bob’s Burgers) will play Ashley, a sci-fi fan who romances a member of the team

- Lauren Weedman (Hacks) will play Pam, a retired nurse who returns when the hospital is understaffed

- Frankie Quiñones (What We Do in the Shadows) will play Leslie, a security guard into all the good gossip

- Lauren Lapkus (Good Girls) and Tim Baltz (The Righteous Gemstones) will play couple who is rushed to the ER after a gender reveal party disaster

- Jonah Beckett (The Sex Lives of College Girls) will play Kyle, a college student admitted with a strange illness

- Jeremiah Brown (Love Island USA) will play Jeff, Kyle’s Ultimate Frisbee-playing roommate

https://tvline.com/casting-news/the-...-3-1235528503/

[TMC]

Golden State Warrior Draymond Green to guest on 'St. Denis Medical'

[JamesG]

"St. Denis Medical" Season 2 Casts Adam Rippon, Paul Scheer, Wayne Knight, Jessica Lowe, Jared Goldstein (EXCLUSIVE)
by Joe Otterson
Oct. 30, 2025


“St. Denis Medical” is continuing to add to its guest star roster for Season 2:


- Olympic gold medalist Adam Rippon will play a male patient who must convince Bruce of his ailments.


- Paul Scheer (The League) will play Ruben, a brother of a patient who needs a kidney transplant.

Even though he butts heads with his brother, he works with the St. Denis Medical doctors behind the scenes to save his brother’s life.


- Wayne Knight (Seinfeld) will play Dr. Axler, a gruff cardiologist who frequently butt heads with Ron.

Tensions reach an all time high when he pokes fun at a medical call made by Ron.


- Jessica Lowe (Wrecked) will play Violet, A cheery, somewhat odd woman who comes into St. Denis to win back her ex-husband, shocking the St. Denis staff.


- Jared Goldstein (Dollface) will play a technician operating a new health screening machine at St. Denis.

https://variety.com/2025/tv/news/st-...er-1236566129/