I noticed that quite a few people from sitcoms became more popular than the rest of the cast or made it big.

Examples I thought of:

Growing Pains - Leonardo DiCaprio, Brad Pitt, Matthew Perry
Full House - Olsen Twins
Fresh Prince of Bel Air - Will Smith
Andy Griffith Show/Happy Days - Ron Howard
Who's the Boss? - Alyssa Milano
Clarissa Explains It All - Melissa Joan Hart
Bosom Buddies - Tom Hanks
The Jamie Foxx Show - Jamie Foxx
The Facts of Life - George Clooney (congrats for winning the Golden Globe)

Any others?

Michael J. Fox - Family Ties
Ashton Kutcher - That 70's Show

that haven't been mentioned yet...

Robin Williams (Mork And Mindy)
Billy Crystal (Soap)
Janet Jackson (Good Times, Diff'rent Strokes, Fame)
Queen Latifah (Living Single)

John Travolta(Welcome Back Kotter)
Danny Devito(Taxi)

I noticed that quite a few people from sitcoms became more popular than the rest of the cast or made it big.

Examples I thought of:

Growing Pains - Leonardo DiCaprio, Brad Pitt, Matthew Perry

Any others?

Brad Pitt also got a big start on "Dallas," where he played Charlie's boyfriend.

Jennifer Aniston from Friends
Sarah Jessica Parker from Sex in the City
Will Smith from the Fresh Prince Bel-Air

goldie hawn good morning world

Hilary Duff, "Lizzie McGuire"

Sarah Jessica Parker from Sex in the City

Square Pegs would be a better comparison. Sarah Jessica Parker was already pretty famous when Sex And The City started, Sex just managed to make her a bigger star than she'd been beforehand.

Shia LaBeouf - Even Stevens (maybe)

The Rock-WWE(well he is a huge movie star now;) even though he's a better wrestler:rolleyes: )

I don't think he was on a sitcom. Unless you consider Raw one.

Shia LaBeouf - Even Stevens (maybe)
He did. His movie was on top of the box for three weeks until Spider-Man came.

Leonardo DiCaprio and Tom Hanks immediately came to mind, but I see they were already mentioned.

Bruce Willis (Moonlighting)
Courtney Cox - (Friends) Scream(1-3)
Would Carol Burnette count?- (Mamas Family, CB Show) Annie
Debra Messing (Will and Grace)
George Cloony (Facts of Life, Roseanne)
Johnny Depp (21 Jump Street)
Gena Davis (Sara, Family Ties guest star) - The Fly, Thelma & Louis....
Alanis Morrisette (You Can't Do That On Television)
Jamie Foxx, Jim Carrey, Jennifer Lopez, Wayan Brothers- (In Living Color)

William Shatner and Leanord Nimoy-Star Trek
Patrick Stewart, Jonathan Frakes, Brent Spiner-Star Trek: The Next Generation

David Cassidy...The Partridge Family

Molly Ringwald from the first season of Facts of Life became big in a few huge 80s movies.

Martin Lawrence from Martin was in a few huge movie hits like Bad Boys 1 & 2, Big Mama's House 1, 2, 3 and It's a Thin Line Between Love & Hate, etc....

melissa mccarthy mike and molly

Rosie Perez In Living Color.

The Wayans Family.