A title shared by more than one TV series

[JamesG]

Line of Fire (History, 2002)

Short-lived docu-series featuring historical battlefields in animated scenes.



Line of Fire (ABC, 2003)

Short-lived crime show featuring Leslie Bibb and Jeffrey D. Sams as rookie FBI agents.

[JamesG]

Acapulco (NBC, 1961)

Short-lived adventure series starring Ralph Taeger and James Coburn.



Acapulco (Apple TV+, 2021-present)

Series inspired by the 2017 film How to Be a Latin Lover.

[JamesG]

Saints and Sinners (NBC, 1962-63)

Short-lived show starring Nick Adams as newspaper reporter Nick Alexander, a character he first played on "The Dick Powell Show".



Saints & Sinners (MyNetworkTV, 2007)

Short-lived telenovela that works as a modernized Romeo & Juliet.



Saints & Sinners (Bounce TV, 2016-2022)

Primetime soap, starring Vanessa Bell Calloway, focusing on the members of a Baptist Church in a small town in Georgia.

[JamesG]

Escape (CBS, 1950)

Short-lived anthology series, narrated by William Conrad, featuring people attempting to deal with danger, the supernatural, or some other bizarre situation.



Escape (NBC, 1973)

Short-lived anthology series, narrated by Dragnet's Jack Webb, featuring people getting out of dangerous situations.

[biffbronson]

Worth a mention though not exact matches:
Cimmaron City 1958-59
Cimmaron Strip 1967-68

[JamesG]

Lifeline (NBC, 1978)

Short-lived anthology series focusing on successful doctors of the time.



Lifeline (YouTube Red, 2017)

Short-lived science-fiction series starring Zach Gilford and Sydney Park.

[JamesG]

Games People Play (NBC, 1980-81)

Short-lived reality series, hosted by Bryant Gumbel, on unusual competitions.



Games People Play (BET, 2019-2021)

Drama series focusing on men and women involved in professional sports, starring Lauren London.

[JamesG]

Think Fast (ABC, 1949-1950)

Short-lived quiz show.



Think Fast (Nickelodeon, 1989-1990)

Short-lived children's game show.

[JamesG]

Party Girl (Fox, 1996)

Short-lived sitcom based on the movie, starring Christine Taylor.



Party Girl (Discovery Home, 2005)

Short-lived reality show focusing on a party planner throwing elaborate parties in NYC.

[JamesG]

Downtown (CBS, 1986-87)

Short-lived crime series starring Michael Nouri.



Downtown (MTV, 1999)

Short-lived animated series focusing on NYC urban life.

[JamesG]

The Club (Spike TV, 2004-05)

Short-lived reality show focusing on ICE, a Las Vegas nightclub.



The Club (MLB Network, 2010)

Short-lived reality show focusing on the Chicago White Sox.

[JamesG]

Couples Therapy (VH1, 2012-15)

Reality show where reality stars receive relationship advice.



Couples Therapy (Showtime, 2019-present)

Reality show that shows real-life couples in couples therapy who agreed to have their sessions filmed.

[JamesG]

Broke (YouTube Red, 2017)

Streaming comedy series starring Quinta Brunson.



Broke (CBS, 2020)

Short-lived sitcom starring Jaime Camil and Pauley Perrette.

[JamesG]

Doc (CBS, 1975-76)

Short-lived sitcom starring Barnard Hughes.



Doc (PAX TV, 2001-04)

Medical drama starring Billy Ray Cyrus.

[JamesG]

For Better or Worse (CBS, 1959-1960)

Short-lived soap opera starring Jim Bannon.



For Better or Worse (TBS/OWN, 2011-17)

Series based on Tyler Perry's Why Did I Get Married? films.