A couple of the examples you mention I can understand the different actors.
Both Dorothy's sister Gloria and Rose's daugher Kirsten first appeared in Season 1 and then not until Season 7. It's not surprising there would be different actors after a six year gap.
I believe you are mistaken on Dorothy's son Michael. The same actor played him 3 times. It's the character's age that kept changing - he was 29 in Season 2, 23 in Season 3 and 30 in Season 5. In his last episode, Dorothy's grandchild to be was forgotten.
Blanche's daugter Janet was constantly mentioned during the show's run, but the character didn't show up until the 2nd last episode of the series - the episode where Rose has a heart attack. It's also the episode with the 2nd Kirsten. It was like GG felt like they had to finally show Janet. They really de-aged her.
As for Blanche's daughter Rebecca, by Season 5 GG had new writers and that could explain the major character overhaul.
There is much more I can say, but I am running out of time now.
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