DeWitt's rep released a statement Friday saying: "Joyce is shocked and heartbroken and so sad for his family. She cannot find words to express her sorrow. Such a great loss to the joy in the world."

Meanwhile, Somers, who was interviewed on Fox's Good Day Live, said she burst into tears when she heard the news. "So much was said about what [conflict we had] when we worked together, but I just loved John Ritter, and I loved John Ritter when we worked together."

Richard Kline, who played Larry on the sudsy sitcom, also released a statement saying: "John was a dear friend and someone who's talent I idolized. My life and my work was enriched by knowing him. The world has lost one of its funniest people. My heart goes out to Amy, the children, his brother Tom and mother Dorothy. I will miss him deeply."