not too many series like this, esp sitcoms:

Bill Cosby Show (1969-71) is the only sitcom that I can think of but I believe there are others.

dramas:

Columbo
Cannon
Murder She Wrote (i think?)
The Fugitive
Run for Your Life

You've got to have some personality to be the only regular in a non-anthological series. Don't think any network would take a chance doing something like this today. If the actor can't do the show, the show is over (that's what caused the Fugitive to end- David Janssen was burnt out from carrying the whole load of the series).

You're right - Angela Lansbury was the only regular on Murder, She Wrote.

Does anyone remember a dramatic series that ran on NBC, from 1980 to 1982,
titled Here's Boomer? It starred Boomer, a homeless little dog that "helps some people and humbles others" (to quote TV Guide). I also remember a syndicated series (produced in Canada, I think) titled The Littlest Hobo, about a German shepherd that roamed all over the country helping people in distress. Each of those series had one regular (you didn't
say the regular had to be a human). :lol:

Branded (western)

Does anyone remember a dramatic series that ran on NBC, from 1980 to 1982,
titled Here's Boomer? It starred Boomer, a homeless little dog that "helps some people and humbles others" (to quote TV Guide). I also remember a syndicated series (produced in Canada, I think) titled The Littlest Hobo, about a German shepherd that roamed all over the country helping people in distress. Each of those series had one regular (you didn't
say the regular had to be a human). :lol:
I used to watch Here's Boomer. :lol:

also with THE FUGITIVE David Jannsen also decided he didn't want to do it anymore because they would film it on location around the country; and he used to get physically tired; since he was in almost every scene.

Each of these series had only one primary regular:

Sea Hunt (Lloyd Bridges)
The Loner (Lloyd Bridges)
The Invaders (Roy Thinnes)
Then Came Bronson (Michael Parks)

The Twilight Zone only had one regular Rod Serling.
Alfred Hitchcock Presents (Alfred himself)
Night Gallery (Rod Serling)
Ghost Story only had one regular, Sebastian Cabot then after half a season he was dropped and the show had no regulars, LOL.

The Twilight Zone only had one regular Rod Serling.
Night Gallery (Rod Serling)


I thought about these yesterday but decided that since Rod only served as host and didn't appear in any episodes (except for one) that he shouldn't count. Rod wasn't seen on camera during the first season of TZ until the last episode where he made a cameo appearance.

True however, he was still part of the show even though you only heard him.