https://screenrant.com/best-cartoon-villains-animated-shows-ranked/

Great heroes need great villains, and the best animated TV shows have created some unforgettable evildoers in a variety of genres over the years.

Yosemite Sam
Wile E Coyote, Super Genius
Boris Badenov & Natasha Fatale
Snidely Whiplash
Fearless Leader
Uniblab
Dr. Zin
Dick Dastardly & Muttley
The Hooded Claw
The Legion of Doom
Injun Joe

I didn't look at the Screenrant list, but they would probably have said, "Yosemite who?" or "Snidely who?"