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"Young Sheldon" can be surprisingly devastating. Welcome to MsMojo, and today we’re counting down our picks for those times “Young Sheldon'' veered far off the course of comedy, and surprised us with heart-wrenching moments. Our countdown includes Meemaw loses her house, Paige shares her story, Mary gets fired, and more! Which heartbreaking moment had YOU reaching for the tissues?

No one showing up for Sheldon's Nobel gathering was the saddest because not even Dr. S. was there for him.

God bless you always!!!

Holly

P.S. I wonder if anything more will happen with Paige.

No one showing up for Sheldon's Nobel gathering was the saddest because not even Dr. S. was there for him.

God bless you always!!!

Holly

P.S. I wonder if anything more will happen with Paige.