In light of all the fuss about stuff disappearing from streamers, how about shows that you now can only find (https://tvtropes.org/pmwiki/pmwiki.php/Main/KeepCirculatingTheTapes) on YouTube?

Amen has never been available on DVD. It was only recently added to Tubi.

These have never been released on DVD or any official streaming platforms as far as I know.

Please Don't Eat the Daisies (1965-1967 - 2 Seasons)
Hello, Larry (1979-1980 - 2 Seasons) - only the crossover episodes with Diff'rent Strokes are available
Private Benjamin (1981-1983 - 3 Seasons)
Still the Beaver / The New Leave it to Beaver (1984-1985, 1986-1989 - 4 Seasons)
Goodnight, Beantown (1983-1984 - 2 Seasons)
Double Trouble (1984-1985 - 2 Seasons)
My Sister Sam (1986-1988 - 2 Seasons)
Valerie / Valerie's Family / The Hogan Family (1986-1991 - 6 Seasons)
Out of This World (1987-1991 - 4 Seasons) - 35 episodes were released on DVD in Germany
Day by Day (1988-1989 - 2 Seasons) - only 1 episode is available on the Family Ties - The Complete Series set
Dear John (1988-1992 - 4 Seasons)
Empty Nest (1988-1995 - 7 Seasons)
Brooklyn Bridge (1991-1993 - 2 Seasons)
Harry and the Hendersons (1991-1993 - 3 Seasons)

These have had only the first season or a limited amount of episodes released on DVD.

Love, American Style (1969-1974 - 5 Seasons)
Chico and the Man (1974-1978 - 4 Seasons) - only 6 episodes
Murphy Brown (1988-1998, 2018 - 11 Seasons)
The Drew Carey Show (1995-2004 - 9 Seasons)
American Dreams (2002-2005 - 3 Seasons)