Despite popular belief, it was the departure of Angus T. Jones, not Charlie Sheen, that derailed "Two and a Half Men".

Although Jake was barely present for the first two seasons of Ashton Kutcher’s tenure, the powers that be felt the need to replace him once he bailed, and in his place (for a season, anyway) was Charlie’s never-before-seen daughter Jenny, whose sole defining trait was that she slept with as many women as her father.

https://tvline.com/lists/worst-tv-characters-cast-additions-the-office-buffy-gilmore-girls/worst-tv-characters-cast-additions-nora-gainesborough-true-blood/