I know she did Awakenings with Robin Williams & Robert De Niro, she also did A League Of Their Own with Tom Hanks & Madonna. Didn't she do Big with Tom Hanks?

Yes, she did "Big" with Tom Hanks she was the director. Here is a list of movies she did:

1986: Jumpin' Jack Flash - Director
1988: Big - Director
1990: Awakenings - Director
1992: A League of Their Own - Director
1992: A League of Their Own - Executive Producer
1993: Calender Girl - Executive Producer
1994: Renaissance Man - Director
1994: Renaissance Man - Executive Producer
1996: Getting Away with Murder - Producer
1996: The Preacher's Wife - Director
1998: With Friends Like These... - Producer
2001: Riding in Cars with Boys - Director

She did Jumpin Jack Flash with Whoopi Goldberg & Renaissance Man with Danny Devito & Gregory Hines? I liked both of those movies. I do remember her doing The Preacher's Wife with Denzel & Whitney Houston.