I suppose that the most simple or easy go-to answer would be to say that Gilda (https://www.datalounge.com/thread/32466316-gilda-radner#) sadly got ill and died young from cancer. But I do naturally wonder had she had been able to remain healthy, would she (https://www.vulture.com/2012/03/the-lost-roles-of-gilda-radner.html) for example, been perfect for a sitcom?

She was on Broadway and released an album and had other successes along the way but I expect she would have had kids and been busy with them. Who knows if she would have continued in show business?

She made several movies also. It was due to her getting sick that she quit doing things. I think she would have been a big success.