Quentin Tarantino’s Once Upon a Time in Hollywood presented Julia Butters with an opportunity that she just couldn’t pass up, and ultimately resulted in her departure from the ABC comedy.

Giselle Eisenberg replaced Butters as Anna-Kat, the youngest child of Katie and Greg Otto, in the fifth (and what would be final) season of the series.

https://tvline.com/lists/recast-tv-roles-explained/american-housewife-anna-kat/