It (https://en.wikipedia.org/wiki/List_of_Who%27s_the_Boss%3F_episodes) could either be about (https://web.archive.org/web/20061031122842/http://www.jumptheshark.com/w/whostheboss.htm):

Sam does something that Tony does not like.

Tony and Angela have sexual tension/proper working relationship tension.

Jonathan is being picked on, or has some sort of stupid "adolescent" problem (Sam can have these too, although they usually lead to her having a problem with Tony).

Angela has trouble at work.

Tony/Angela dates someone, and the other is upset.

Tony and Angela have a misunderstanding based upon class.

An "old friend" returns for some reason or other.