I don't necessarily mean an out and out troubled production (https://tvtropes.org/pmwiki/pmwiki.php/TroubledProduction/LiveActionTV) in regards to cast in-fighting or egos clashing.

I'll give you an example, It's a Living (http://comforttv.blogspot.com/2017/08/top-tv-moments-ann-jillian.html). When the show premiered on ABC in 1980-81, its season was shortened (http://thelandofwhatever.blogspot.com/2018/04/classic-tv-its-living-1980.html) by a Screen Actors Guild strike (https://en.wikipedia.org/wiki/Screen_Actors_Guild#Strike_and_Emmy_Awards_boycott_of_1980). In the second season (http://www.crazyabouttv.com/itsaliving.html), the name of the show was changed (http://www.poobala.com/itsandmaking.html) to Making a Living. The show was canceled by ABC after its second year but revived for the first run syndication (http://articles.latimes.com/1985-03-04/entertainment/ca-24343_1_tv-syndication) market three years later (where it aired for another four years).

9 to 5 ran from 1982-88, but only aired five seasons, and only three were "full" seasons.

Season 1, spring 1982: midseason replacement, 6 or so episodes.
Season 2, 1982-83: full season
Season 3, fall 1983: 4 or so episodes, canceled a month into the season after ratings drop drastically, the result of James Komack's retooling efforts.

The show scored solid ratings the first two seasons, finishing 15th in 1982-83.

Season 4: 1986-87 (full season, now in syndication)
Season 5: 1987-88 (full)

The show actually had enough episodes for syndicated reruns, but outside of airing on TBS in the late-80s, I don't believe it's aired anywhere except for maybe a one-time deal on TV Land.

We Got it Made is another example...reference books mention it as airing from 1983-88, but it only aired during the 1983-84 season on NBC, then as part of NBC's failed "Prime Time Begins at 7:30" block from 1987-88.

Honestly, I think you could add a few shows that didn't do well on the networks, but fared much better in syndication, to this list. Charles in Charge comes to mind...the syndicated version dumped everyone but Scott Baio and Willie Aames.

9 to 5 ran from 1982-88, but only aired five seasons, and only three were "full" seasons.

Season 1, spring 1982: midseason replacement, 6 or so episodes.
Season 2, 1982-83: full season
Season 3, fall 1983: 4 or so episodes, canceled a month into the season after ratings drop drastically, the result of James Komack's retooling efforts.

The show scored solid ratings the first two seasons, finishing 15th in 1982-83.

Season 4: 1986-87 (full season, now in syndication)
Season 5: 1987-88 (full)

The show actually had enough episodes for syndicated reruns, but outside of airing on TBS in the late-80s, I don't believe it's aired anywhere except for maybe a one-time deal on TV Land.

We Got it Made is another example...reference books mention it as airing from 1983-88, but it only aired during the 1983-84 season on NBC, then as part of NBC's failed "Prime Time Begins at 7:30" block from 1987-88.

Honestly, I think you could add a few shows that didn't do well on the networks, but fared much better in syndication, to this list. Charles in Charge comes to mind...the syndicated version dumped everyone but Scott Baio and Willie Aames.

Also, the first season (https://people.com/archive/picks-and-pans-review-9-to-5-vol-17-no-12/) of 9 to 5 (https://uproxx.com/tv/when-movies-become-shows-9-to-5-series/) was shot on film while the rest the series was shot on video tape (like Newhart, but in reverse).

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Good picks for shows with very troubled production histories, guys.

Temperatures Rising/The New Temperatures Rising Show/back to Temperatures Rising--one normal 26 episode season 1972-73, and abbreviated, re-tooled 13 episode season two in 1973, and a third, re-re-tooled summer replacement 7 episode season 3 in 1974.

Joey Bishop Show had an unusual production history. The 1st season episodes were mostly black and white, NBC produced a few episodes in color for that inaugural season. Then in seasons 2 and 3, still on NBC, all the episodes were in color. Then for it's 4th and final season, the series moved to CBS and the episodes returned to black and white.

The Naked Truth (1995-1998) starring Tea Leoni.

The show first started out on ABC and then was moved to NBC in 1996. Once it moved to NBC, the network retooled the show, adding in new characters and making the show less outlandish and kinda cynical. The second season didn't premiere until 1997, where it aired with only 13 episodes and was a midseason replacement. Then for season 3, they retooled the show AGAIN, dumped most of the main characters and the setting in exchange for new main characters and a new workplace setting. Also, for whatever reason, they decided to make one of the main characters, who was mentally challenged, suddenly no longer mentally challenged. Not really a big deal, but thought that was kinda weird to get rid of something the character was known for, but hey, it's NBC.

One show that comes to mind is the Jamie Lee Curtis sitcom "Anything But Love" which co-starred comic Richard Lewis and aired on ABC from 1989-1992 for four seasons (and 56 episodes):

The show debuted in 1989 for a very short first season (about six episodes), which garnered respectable ratings but ABC decided to retool the series completely. The entire supporting cast was fired and replaced with new characters and moved the show to a new timeslot where ratings fell dramatically.

The third season did not debut until February 1991, with additional cast changes and a lot of promotion from ABC. Ratings were strong enough for a fourth season, with again came with cast changes. In August 1991, the show was moved to a new timeslot Wednesdays at 10pm as part of a short-lived block of programming called "The Hump" and ratings fell hard.

In an unusual move the series was not cancelled by ABC but instead by the production company who calculated that the series would likely not be renewed and that the series would never be profitable in syndication.

“9 to 5” is the winner for me. It was retooled almost every year. The second season, it got a new Mr. Hart (Peter Bonerz replaced Jeffrey Tambor). The third season got a massive retool, with a new producer (James Komack), a new third secretary (Leah Ayers replaced Valerie Curtin), a new setting (the secretaries are now also roommates!), a new kid (Violet’s son), and a new salesman (George Deloy replaced Herb Edelman). And the show went to videotape. The fourth season brought back Curtin along with Rachel Dennison, along with a new cast and setting and production team.

It’s no wonder it has never played much in syndicated reruns - too many format changes and changes in tone.

“The Doris Day Show” got retooled a lot, too. But those retools weren’t as jarring as the ones for “9 to 5”.