Danica McKellar winner copper the wonder years
Tiffani Thiessen Kelly Kapowski saved by the bell
Danielle Fishel Topanga Lawrence- boy meets world
Kellie Shanygne Williams laura winslow family matters
Mallory Keaton Justine Bateman family ties
Melanie Wilson jennifer on perfect strangers
Rebeca Arthur mary ann on perfect strangers
Judith Light Angela Bower who's the boss?
Markie Post as Christine Sullivan night court

If you mean 2 girls that play friends on a TV series it would be the 2 girls on Broad City. Cheers!