If you had to pick just one

Season One, no doubt.

Aileen Conway
Jule/Dottie Caylor
Jerry Strickland and his circlestansive evidence
Kurt McFall
Doreen Picard/Susan LaFerte
Gail DeLano
D.B. Cooper
Don Henry & Kevin Ives; The Boys on the Tracks
The Son of Sam
Harold & Thelma Swain
Annie Hearin
Mark/Christi Nichols
Kurt Sova
Father Reynaldo Rivera & Father John Kerrigan
Rogest Cain
Jenny Pratt/Curtis Croft
Clarence & Geneva Roberts
Matthew Chase
Stephen/Marilu Geri
Lee Selwyn
Michael Rosenblum
Jeremy Bright
Micki Jo West
Dorothy Allison's story
Kathy Hobbs
Angelo Desidari
The Alcatraz Special
Mickey & Trudy Thompson
Joyce McLain
The LA Bank Tunnel Robbers
Permon Gilbert
Don Smith
Lisa Marie Kimmell
Audrey Moate
John Mooney/TK Harty/Elmo Florence
Liz Carmichael & The Dale
Tim/Terri McClure
Gus Hoffman
Patsy Wright
Kari Lynn Nixon
Dexter Stefonek & The Hot Jock

Plus, the plethora of segments that didn't make it to Amazon Instant Video including the Mike Reimer & Diana Robertson case, which is one of the best ever.

That's a tough list to beat.

The early ones were the best. Seasons 1 and 2 were both great, it's hard to pick between them for me. I'll go with season 1 with the mystery rock segment being the tiebreaker

Season One, no doubt.

Aileen Conway
Jule/Dottie Caylor
Jerry Strickland and his circlestansive evidence
Kurt McFall
Doreen Picard/Susan LaFerte
Gail DeLano
D.B. Cooper
Don Henry & Kevin Ives; The Boys on the Tracks
The Son of Sam
Harold & Thelma Swain
Annie Hearin
Mark/Christi Nichols
Kurt Sova
Father Reynaldo Rivera & Father John Kerrigan
Rogest Cain
Jenny Pratt/Curtis Croft
Clarence & Geneva Roberts
Matthew Chase
Stephen/Marilu Geri
Lee Selwyn
Michael Rosenblum
Jeremy Bright
Micki Jo West
Dorothy Allison's story
Kathy Hobbs
Angelo Desidari
The Alcatraz Special
Mickey & Trudy Thompson
Joyce McLain
The LA Bank Tunnel Robbers
Permon Gilbert
Don Smith
Lisa Marie Kimmell
Audrey Moate
John Mooney/TK Harty/Elmo Florence
Liz Carmichael & The Dale
Tim/Terri McClure
Gus Hoffman
Patsy Wright
Kari Lynn Nixon
Dexter Stefonek & The Hot Jock

Plus, the plethora of segments that didn't make it to Amazon Instant Video including the Mike Reimer & Diana Robertson case, which is one of the best ever.

That's a tough list to beat.

^^^^EXACTLY this...it's amazing how almost all of my favorite segments were from Season One. I feel like I could take season one, and then pick specific segments from other seasons, to create one master season of segments that would be all I needed to watch.

Season 1

Season one. Best mysteries. Didn't go off on a tangent like later seasons!

1.

GOOD QUESTION!!!!

This one made me think for a while.

I am going to have to say BELIEVE IT or NOT!!!!
my favorite season or (seasons) were the Lifetime ones (2001 & 2002)

I like how when I watched an episode in those seasons, I could watch 1 or 2 new cases and then 2 or 3 "old cases."

That is how Spike TV should have done the Farina version!!!!!!!!!!!!!

Season 1 and I loved the Specials with Ray Burr and Karl Malden.

Donald Kemp
The Unabomber

To name a couple.

Season 4

I would have to agree with others, regarding the first season. That collection of episodes probably generated the greatest amount of fear and confusion in me (when I first saw many of those segments) than any other season's collection.

However, in fairness, didn't Season One have more episodes than some of the other seasons?

Season 1 and it's no contest. Many of the other seasons are strong, but I still vividly remember watching Season 1 on TV when it originally aired and I had never seen anything quite like it.

I think I like season 1 best also.

Will be getting prime again this weekend so have a few seasons to catch up on.

Which season was Keith Warren on? Haven't seen that case(stack version) in quite a while.

When I first got prime I skipped around the episodes and prob missed quite a few but this time I'll start at season 1 and watch them in order

Aww, well now I feel like I've burned through the best seasons! I binge-watched all 7 in 2.5 months.