Who are some sitcom characters with a brother or sister said to have died, or died during a series?

For example, on Family Affair, the character Bill Davis had a deceased brother named Bob.

On The Golden Girls, Dorothy Zbornak's brother Phil, died during the series run.

On Mama's Family, Thelma's sister Fran died.

The whole premise of "Full House" was that Uncle Jesse's sister Pam had died in a car crash when her car was hit by a drunk driver.
(And thus, Pam's husband, Danny, needed help raising their three girls, so Uncle Jesse and Joey moved in to help out.)
Later on in the series, Jesse's grandfather also died.

Chuck Cunningham on "Happy Days" and Judy Winslow on "Family Matters" might as well have been killed off.

Well, he wasn't deceased ON the show, but Archie Bunker's brother came back to make up with him and at that point he was terminally ill.

On "Family" Nancy, Willie, and Buddy had a brother name Timmy who died of drowning when he was ten.

Winnie Cooper. The Wonder Years. That was sort of a dram-com though.

Her brother Brian (wasn't it?) died in the first or second episode off screen in Nam.

Major Winchester had a brother who died in childhood.

The Office = Kelly Kapoor's sister.

On the episode of the Cosby Show "Cliff Babysits", he's watching the twins Winnie and Nelson while everyone is at a Michael Jackson concert, he mentions that he had a brother James Aloysius Huxtable that died when he was a boy. Cliff used to have to help watch him sometimes. He died of pneumatic fever. Theo's middle name was Aloysius, named after his late uncle James. :)

Also, even though it's not a sitcom, on Dr. Quinn Sully mentions that he had a brother that died after being thrown from a horse. Sully is afraid of horses after that until Cloud Dancing helps him get over his fear.

Winnie Cooper. The Wonder Years. That was sort of a dram-com though.

Her brother Brian (wasn't it?) died in the first or second episode off screen in Nam.

It was Winnie's brother Brian, and it happened in the first episode.

Winnie Cooper. The Wonder Years. That was sort of a dram-com though.

Her brother Brian (wasn't it?) died in the first or second episode off screen in Nam.

Yes; Brian Cooper was killed in Vietnam in the first episode of the show.

I believe Olivia said in one episode that she gave birth to a stillborn on The Waltons around the time Jim Bob was born, if that counts.

Certainly that counts, as far as I'm concerned.

On Two and A Half Men, Alan Harper's brother Charlie is dead.

On Little House on the Prairie Mary, Laura, and Carrie had a little brother Charles Jr. who died as a baby.

I believe Olivia said in one episode that she gave birth to a stillborn on The Waltons around the time Jim Bob was born, if that counts.I think that was Jim-Bob's twin that didn't make it.