Rules:

1. Regular or semi-regular roles only, guest appearances don't count
2. Sitcoms, dramas, etc...
3. One per non-consecutive turn

Bernie Kopell and Dick Gautier:

Get Smart and When Things Were Rotten

Betty White (Ellen) & Rue McCallahan (Aunt Fran) = Mama's Family
Betty White (Rose) & Rue McCallahan (Blanche) = Golden Girls

Bea Arthur (Maude Findly) & Rue McCallahan (Vivian) = Maude
Bea Arthur (Dorothy) & Rue McCallahan (Blanche) = Golden Girls

Betty White (Ellen) & Rue McCallahan (Aunt Fran) = Mama's Family
Betty White (Rose) & Rue McCallahan (Blanche) = Golden Girls

Bea Arthur (Maude Findly) & Rue McCallahan (Vivian) = Maude
Bea Arthur (Dorothy) & Rue McCallahan (Blanche) = Golden Girls

I knew it. :lol:

Jack Klugman and Garry Walberg:

The Odd Couple and Quincy M.E.

Bill Cosby and Phylicia Rashad: Cosby Show (NBC, 1984-92) and Cosby (CBS, 1996-2000).

Andy Griffith and Don Knotts:

The Andy Griffith Show and Matlock

I knew it. :lol:
LOL :lol:

Some more Mama's Family & The Carol Burnett Show (Vicki Lawrence & Carol Burnett; Mama & Eunice)

Staci Keenan and Christopher Castile Going Places (1990-1991) and Step by Step(1991-1998)

Tiffani Amber Thiessen (Kelly Kapowski, Valerie Malone) & Tori Spelling (Violet Bickerstaff, Donna Martin) = Saved By the Bell & Beverly Hills, 90210

Fred Gwynne and Al Lewis:

Car 54, Where Are You? and The Munsters

Lauren Vélez and David Zayas:

"Oz" and "Dexter"

Clifton Davis and Jester Hairston of That's My Mama (1974-1975) and Amen (1986-1991)

Michael Landon and Victor French:

Little House On the Prairie and Highway to Heaven

Lynda Goodfriend and Scott Baio of "Who's watching the kids (1977-1978) and Happy Days (1974-1984)

Delta Burke & Dixie Carter: Filthy Rich (1982) & Designing Women (1986)

Kristoff St. John and Tricia Cast:

The Bad News Bears and The Young & The Restless

Scott Baio and Henry Winkler - Happy Days and Arrested Development

Lucille Ball and Gale Gordon The Lucy Show, Here's Lucy, Life With Lucy.

Lucille Ball, Vivian Vance - I Love Lucy, The Lucy Show

Ozzie and Harriet Nelson-The Adventures of Ozzie and Harriet, and Ozzie's Girls!

Jane Leeves and Wendie Malick

Frasier and Hot In Cleveland

Doug Savant and Marcia Cross

Melrose Place & Desperate Housewives

Betty White and Georgia Engel

The Mary Tyler Moore Show and The Betty White Show (1977)

Maureen McCormick and Eve Plumb:

The Brady Bunch and The Brady Brides

Forrest Tucker & Larry Storch:

F Troop & The Ghostbusters

Betty White and Georgia Engel

The Mary Tyler Moore Show and The Betty White Show (1977)


Betty White and Gloria Engel :

The Mary Tyler Moore Show
The Betty White Show
and....

HOT IN CLEVLAND!!! :D

James Garner & Stuart Margolin-NICHOLS, THE ROCKFORD FILES & BRET MAVERICK

Keenan Thompson and Kel Mitchell

All That
Keenan and Kel
Steve Harvey Show

Keenan Thompson and Kel Mitchell

All That
Keenan and Kel
Steve Harvey Show
They were also in the movie Good Burger together :)

Danny Thomas and Marjorie Lord:

Make Room for Daddy and a short-lived revival, Make Room for Granddaddy

(also featured Rusty Hamer and Angela Cartwright in both)

Kevin Kubecheskie and Christine McGlade of You can't do that on Television and Turkey Television.

William Shatner, Leonard Nimoy, DeForest Kelley , George Takei, Nichelle Nichols, James Doohan & Majel Barrett:

Star Trek
Star Trek The Animated Series

Jackie Gleason and Art Carney in "The Honeymooners" and "The Jackie Gleason Show"

Molly Ringwald and Mindy Cohn:

"The Facts of Life" and "The Secret Life of the American Teenager"

Patrick Duffy and Sasha Mitchell - Dallas and Step by Step

B.D. Wong and Chris Meloni:

"Oz" and "Law and Order: SVU"

Martin Landau and Barbara Bain - Mission: Impossible and Space: 1999

Shelley Fabrares and Nanette Fabray

One Day At a Time and Coach

Lynda Goodfriend and Scott Baio of "Who's watching the kids (1977-1978) and Happy Days (1974-1984)
They were also both on Blansky's Beauties!

Caren Kaye, Lynda Goodfriend & Scott Baio

Blansky's Beauties and Who's Watching The Kids

Miranda Cosgrove & Jerry Trainor-Drake & Josh

Miranda Cogrove & Jerry Trainor-iCarly

Sarah Gilbert and Johnny Galecki and Laurie Metcalf on The Big Bang Theory
Matthew Perry and Bradley Whitford The West Wing, Studio 60 and Go On
Matthew Perry and Courtney Cox Go On
Lisa Kudrow and David Schwimmer on Web Therapy
Cougarotown Krista Miller and Ken Jenkins from Scrubs
Zack Braff and Donald Faison on The Exes
Kristen Johnston and Wayne Knight on The Exes
Adam Baldwin and Nathan Fillion were on Firefly and on Castle
David Hyde Pierce, Kelsey Grammer, were on The Simpsons
Larry Hagman and Barbara Eden on Dallas
Tempest Bledsoe and Keshia Knight Pulliam on Guys with Kids
Sean Hayes and Debra Messing on SMASH
Busy Phillips and Jason Segel How I Met Your Mother
Matthew Perry and Allyson Janney West Wing and Mr Sunshine
Matt LeBlanc and Adam Goldberg Friends and Joey

Sarah Gilbert and Johnny Galecki and Laurie Metcalf on The Big Bang Theory
Matthew Perry and Bradley Whitford The West Wing, Studio 60 and Go On
Matthew Perry and Courtney Cox Go On
Lisa Kudrow and David Schwimmer on Web Therapy
Cougarotown Krista Miller and Ken Jenkins from Scrubs
Zack Braff and Donald Faison on The Exes
Kristen Johnston and Wayne Knight on The Exes
Adam Baldwin and Nathan Fillion were on Firefly and on Castle
David Hyde Pierce, Kelsey Grammer, were on The Simpsons
Larry Hagman and Barbara Eden on Dallas
Tempest Bledsoe and Keshia Knight Pulliam on Guys with Kids
Sean Hayes and Debra Messing on SMASH
Busy Phillips and Jason Segel How I Met Your Mother
Matthew Perry and Allyson Janney West Wing and Mr Sunshine
Matt LeBlanc and Adam Goldberg Friends and Joey

Rules:

1. Regular or semi-regular roles only, guest appearances don't count
2. Sitcoms, dramas, etc...
3. One per non-consecutive turn

Rosetta LeNoire and Thelma Hopkins...

"Gimme a Break"...
SWr36-8vb78

"Family Matters"
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Do visual aides count? I tried finding the 2nd Seasom intro to "Family Matters", but this is as close as I could get.

Florence Henderson and Robert Reed : The Brady Bunch & The Bradys

Jennifer Finnigan & Josh Cooke
on Committed 2005& Better with You 2010 both lasted 1 season

Richard Mulligan &Dinah Manoff
on Soap 1978 he played her stepfather- in law

Billy Gardell & Reno Wilson
on Heist( 2006) lasted six episodes & Mike & Molly ( 2010)

Linda Lavin &Mark Feuerstein
mother& son on Conrad Bloom 1998 & 9jkl 2017

James Buckley and Joe Thomas:

'The Inbetweeners' and 'White Gold'

tori spelling & jennie garth
on Beverly Hills 90210 1990 & Mystery Girls 2014

Daniel Dae Kim & Jorge Garcia
Lost 2004 & Hawaii Five o 2010

Ada Maris & Carlos Lacámara
Nurses 1991 & The Brothers Garcia 2000

Stacy Ferguson and Renee Sands - Kids Incorporated and Great Pretenders
Jerry Orbach and Fred Dalton Thompson - Law & Order and Law & Order: Trial By Jury
Bill Cullen and Don Pardo - The Price Is Right, Three on a Match, and Eye Guess
Peter Tomarken and Rod Roddy - Press Your Luck and Hit Man
Joseph Wapner and Rusty Burrell - The People's Court and Judge Wapner's Animal Court

Kevin James and Leah Remini.

The King Of Queens and Kevin Can Wait.

Ed.

Lucille Ball & Vivian Vance-I LOVE LUCY and THE LUCY SHOW

Julie Piekarski and Lisa Whelchel
The New Mickey Mouse Club and The Facts of Life

Rhea Perlman and Kirstie Alley -- Cheers (1987-1993) Kirstie (2013-2014)