Some actors and actresses were simply born to play a role, specifically a role in a movie or TV show based on a comic strip or comic book. Some examples:

Arthur Lake as Dagwood Bumstead
Penny Singleton as Blondie Bumstead
Shelley Duvall as Olive Oyl
Robin Williams as Popeye
Ralph Byrd as Dick Tracy
Christopher Reeve as Superman/Clark Kent
Albert Finney as Oliver "Daddy" Warbucks
Aileen Quinn as Annie
John Goodman as Fred Flintstone
Rick Moranis as Barney Rubble
Lynda Carter as Wonder Woman
Ted Cassidy as Lurch
Adam West as Batman/Bruce Wayne
Lou Ferrigno as the Incredible Hulk