Full House - Danny Tanner

Sanford and Son - Fred Sanford

My 3 Sons - Steven Douglas

Amen - Ernest Frye

227 - Rose Holloway (yes, she was a supporting character, but she was a single mom)

The Partridge Family - Shirley Partridge

The Andy Griffith Show - Andy Taylor
Julia - Julia Baker
Mayberry RFD - Sam Jones

Sunshine--Sam Hayden

The Ghost & Mrs. Muir--Carolyn Muir

Petticoat Junction--Kate Bradley

Diff'rent Strokes - Phillip Drummond
The Courtship of Eddie's Father - Tom Corbett
What's Happening - Mrs. Thomas

Switched At Birth - Regina Vasquez

Big Valley, Victoria Barkley Bonanza, Ben Cartwright

Roz Doyle was a single parent to Alice when Frasier ended.

[I]Lassie[I] The First Three and a Half Seasons had Ellen Miller. (Ok, there was "Gramps" but that's a Technicality.

Dramas:

Flipper - Porter Ricks
Baywatch - Mitch Buchanon
Bonanza - Ben Cartwright
The Hardy Boys Mysteries - Fenton Hardy
Matlock - Ben Matlock
Star Trek Deep Space Nine - Cdr. Sisko

Comedies:

The Andy Griffith Show - Andy Taylor
Beverly Hillbillies - Jed Clampett
Courtship of Eddie's Father - Tom Corbett
Frasier - Martin Crane
Gidget - Prof. Russ Lawrence
The Ghost and Mrs. Muir - Carolyn Muir
Mork and Mindy - Fred McConnell
My Little Margie - Vernon Albright
One Day at a Time - Ann Romano
Kate and Allie - Kate McArdle and Allie Lowell
The Partridge Family - Shirley Partridge
Petticoat Junction - Kate Bradley
Sanford & Son - Fred Sanford
That Girl - Lou Marie

'The Lucy Show'- Lucy and Viv

'Here's Lucy'-Lucy

'Gimme a Break'- the Chief

'The Facts of Life'-Beverly Ann

'Mayberry RFD'-Sam

Two of a Kind (a Mary-Kate/Ashley Olsen TGIF show from the 90s) had a single dad raising the twins.

Gilmore Girls -- Loralei was single, but Rory's dad did show up from time to time.

Blossom -- Nick Russo raised his three kids after his ex-wife moved to Paris.

Alice (Linda Lavin)

The Dennis O'Keefe Show - Hal Towne (widower)

Also, on Happy Days, Ashley Pfister (Linda Purl) was a single mom. And additionally regarding My Three Sons, widow Barbara Harper was a single mom prior to her marriage to Steve.

Murphy Brown - Murphy Brown

The Doris Day Show - Doris Martin

The Bob Newhart Show - Howard Bordon

Phyllis - Phyllis Lindstrom

The Beverly Hillbillies - Pearl Bodine

Good Times - Willona Woods

Maude - Carol

That Girl - Lou Marie[/QUOTE]

Lou Marie was not a single father, his wife and Ann's mother was Helen, played by Rosemary DeCamp.

One Day at a Time - Ann Romano
Alice - Alice
Family Affair - Brian Keith's character

Nanny and the Professor -- Prof. Hal Everett

Sitcoms:

Silver Spoons - Edward Stratton raised Ricky after Evelyn bailed on him 10 days after they were married and left Ricky at a military school.

Benson - Governor Eugene Gatling


Non-Sitcoms:

Scarecrow and Mrs. King - Amanda King

Jonny Quest - Dr. Benton Quest

The Nanny Maxwell was a widower
Benson Governor Gatling was a widower as well.
Joey Gina Tribbiani was a single mother
Whos the Boss Angela, Tony, and Mona were single parents
Bailey on Greys Anatomy is a single parent and Dr Mark Sloan has a teen aged daughter and a child from a one night stand, Sophia with Callie
Dallas Bobby was a single parent to Christopher
and even though the other parent was in the picture Miranda on Sex and the City and Rachel on Friends, and also Jack on Will and Grace.