Kirstie Alley for Shelley Long on Cheers: You think Bewitched had it hard, having to recast Darren and hoping nobody would notice and/or care? You think Spin City had it tough, having to replace the beloved Michael J. Fox with the checkered Sheen? Try being Cheers, and having to reconfigure, reimagine and redo a show that, at its heart, had been about Sam (Ted Danson) and Diane (Long). Men's Chuck Lorre and Kutcher would be wise to determine where the show went right because, in the end, Cheers ran longer without Diane/Long than it had with the character or the actress.

Read more: http://www.eonline.com/uberblog/b241721_five_hit_shows_replaced_starsmdashand.html#ixzz1MHuZAT2h

M*A*S*H had a similar story only they had to replace 2 of their stars McLean Stevenson and Wayne Rogers. Enter Harry Morgan and Mike Farrell and the show ran 8 more seasons!

I guess we'll just have to wait and see what happens!!

Kirstie Alley for Shelley Long on Cheers: You think Bewitched had it hard, having to recast Darren and hoping nobody would notice and/or care? You think Spin City had it tough, having to replace the beloved Michael J. Fox with the checkered Sheen? Try being Cheers, and having to reconfigure, reimagine and redo a show that, at its heart, had been about Sam (Ted Danson) and Diane (Long). Men's Chuck Lorre and Kutcher would be wise to determine where the show went right because, in the end, Cheers ran longer without Diane/Long than it had with the character or the actress.

Read more: http://www.eonline.com/uberblog/b241721_five_hit_shows_replaced_starsmdashand.html#ixzz1MHuZAT2h
Cheers wasnt centered around Diane and Sam as much as it was centered around Sam if hed left the show would have tanked and you had such a strong supporting staff Two and a Half Men on the other hand doesnt have that luxury.