The following stars appeared on the show, in order of appearance:

Giovanni Ribisi, Peter Krause, Molly Shannon, Andrea Parker, Jerry Penacoli (twice), Bradley Whitford, Kathy Najimy (three), Connie Stevens (voice), Mary-Kate Olsen, Bob Saget (twice), Alex Trebek (voice), Patrick Warburton (three), Mike Adamle, American Gladiators Nitro, Ice, and Hawk, Christine Taylor (twice), Martha Stewart, Carrie Fisher, Ron Palillo (three), Kathy Griffin, Mary Tyler Moore, Bodhi Elfman, Janeane Garofalo, Thea Vidale, Jay Leno, Mariska Hargitay, John Tesh, The Captain and Tennille, Wolfgang Puck, pop group Devo, Trisha Yearwood, ZZ Top, Florence Henderson, Aaron Neville (twice), Me'Shell NdegeOcello, David Crosby, Sheryl Crow, Queen Latifah, Bonnie Raitt, Brett Butler, Drew Carey, Wayne Newton, Laura Dern (twice), Melissa Etheridge (twice), Gina Gershon (twice), Demi Moore (twice), Billy Bob Thornton (twice), Oprah Winfrey (twice), Dwight Yoakam (twice), k.d. lang (twice), Chastity Bono, Joan Jett, The Bee Gees, Andrea Bendewald, Norman Fell, Angie Dickinson, Louis Gossett Jr., Sean Penn, Emma Thompson, Anne Heche (twice), The Indigo Girls, Rena Sofer, Beatrice Arthur, Orson Bean, Glenn Close, Tim Conway, Cindy Crawford, Linda Ellerbee (twice), Helen Hunt, Christine Lahti, Julianna Margulies, John O'Hurley, Jada Pinkett Smith, Jennifer Aniston, Diahann Carroll, Ted Danson, Phil Donahue, Woody Harrelson, Mary Steenburgen, Ed Begley Jr., and Judge Reinhold.