Co- Creator Bill Prady answered a bunch of great questions from fans about The Big Bang Theory in Variety. It is a must read. The best and most informative Q & A article I have seen. Read it here :

http://weblogs.variety.com/season_pass/2009/05/big-bang-theory-we-didnt-anticipate-how-protective-the-audience-would-feel-toward-our-guys.html

Great article and some very interesting stuff.