Name characters who are sarcastic

Chandler Bing-Friends
Niles-The Nanny
Geoffry-The Fresh Prince
Florence-The Jeffersons

All The Golden Girls

Brent Leroy and Wanda Dollard Corner Gas
Kerry Hennessy 8 Simple Rules

niles crane- frasier
richard karinsky- caroline in the city
darlene connor- roseanne
karen walker- will and grace

Frasier Crane - Cheers, Frasier

Roseanne Connor - Roseanne
Dan Connor - Roseanne

The entire cast of "Facts of Life"
Piper Halliwell- Charmed
Dr. Cox- Scrubs (and Jordan Sullivan at times)
Dana Foster- Step by Step

More to come! This requires some thinking.

Benson DuBois - Benson
Clayton Endicott - Benson
Fred Sanford - Sanford and Son
Sandy Miller - Nurses

Thelma "Mama" Harper- Mama's Family
Sue Ann Niven-Mary Tyler Moore Show
Rhoda Morgenstern- MTM/Rhoda
Harriet Olson-Little House On The Praire
Nellie Olson- Little House On The Praire
Carrie Heffernan- King Of Queens

Kyra- Reba

Charlie Harper - Two And A Half Men

Buffy Summers - Buffy The Vampire Slayer
Cordelia Chase - Angel
Rory Gilmore - Gilmore Girls
Lorelai Gilmore - Gilmore Girls
Veronica Mars - Veronica Mars

Hawkeye - MASH
Bob - The Bob Newhart Show
Alex Keaton - Family Ties
Jerry - Seinfeld
Murphy - Murphy Brown
Dennis - Just Shoot Me
Eric - That '70s Show
Ray - Everybody Loves Raymond
Dr. Cox - Scrubs
Becker - Becker
Jim - The Office
Eric - Entourage

Red Foreman - That '70s Show

Steven Hyde-That 70's Show
Carla Tortelli- Cheers
Nell Harper- Gimme A Break

Dean Winchester - Supernatural

I am surprised that no one said Brian Griffin on Family Guy..

Mr. T - A-Team

Stewie Griffin -Family Guy
Bart Simpson - The Simpsons

Louie DePalma - Taxi -not only we has sarcastic but he was quite a tyrant to everyone in the garage.

John Becker - Becker
Bob - Becker
Eddie Haskell - Leave It To Beaver
Debra Barone - Everybody Loves Raymond
Buddy Sorell and Sally Rogers - The Dick Van Dyke Show
Mr. Ed

Del Boy-Only Fools And Horses
Rimmer-Red Dwarf
Blackadder-Blackadder
Saffy-Ab Fab