List from Encyclopedia of Fictional People:

Doogie Howser (Doogie Howser MD)
Holden Caulfield (Catcher In The Rye)
Kevin MacAllister (Home Alone)
Fred Tate (Little Man Tate)
Alex P. Keaton (Family Ties)
Lisa Simpson (The Simpsons)
Ferris Bueller (Ferris Bueller's Day Off)
Jonny Quest (Jonny Quest)

Who else should be on this list? I say Kevin Arnold (The Wonder Years).

Steven Urkel-Family Matters
Franklin Aloysius Mumford -My Wife And Kids
Carol Seaver-Growing Pains

Malcolm - Malcolm in the Middle

The students on Head of the Class

Stewie on Family Guy.

Will Robinson - Lost In Space

Eddie Haskell (smart in a bad way) on Leave It To Beaver;)

Michael Evans - Good Times

Little Ricky(seasons 6-9)-I Love Lucy. Boy, could that kid play the drums!

Dee Thomas - Whats Happening

Katie Gatling - Benson

Judy Hensler - Leave It To Beaver

Judy Hensler - Leave It To Beaver

Ah yes Judy--Queen of the Snitches. Dee Thomas's hero.

BTW, Dee Thomas (What's Happening) fits this category. She is really smart...just also very annoying.

Danny Partridge (what a little con artist!)
Rusty Williams (MAKE ROOM FOR DADDY/THE DANNY THOMAS SHOW)
Chip Douglas (MY THREE SONS)