Name the sitcoms where marriage between the main characters ruined the chemistry of the show:

The Nanny
The Farmer's Daughter
Get Smart
I Dream of Jeannie

Who's the Boss?-Tony and Angela didn't actually get married on the show, but they got together after years of tension. The writers realized things went flat and wrote in conflicts and separations in the last season to try and get the chemistry back.

I'll go on record as saying that the weddings between Larry and Jennifer plus Balki and Mary Anne on Perfect Strangers ruined the show.

I'll say that the marriage of Angie Falco and Brad Benson of Angie, ruined the show. Angie starred Donna Pescow and Robert Hayes.

Niles and Daphne. Maybe if they'd saved them getting together for the very last show, it would have worked.

Daphne was supposed to be the girl Niles could never have. Plus their becoming a couple meant...NO MORE MARIS!! :( :( :(

One Tree Hill wasn't ruined when NAthan & HAley got married!

Rhoda and Joe - The show immediately ran out of ideas and it was hard seeing Rhoda as a married woman. Plus Valerie Harper and David Groh was not compatible as a couple. They were married too quick into the series.

Joe and Helen's marriage really killed Wings. They were a wonderful couple until they got married.

Rhode and Joe