Ralph and Alice Kramden

Stanley and Helen Roper

Fred and Ethel Mertz

bob and emily hartley

Ed and Trixie Norton

Bob and Emily Hartley. They were going to have a show where Emily became pregnant, but when they showed Bob the script, he said "Fine. But who are you going to get to play my role"?

Dick Louden and his wife on "Newhart". I forget her name.

Ralph and Alice Kramden, because Jackie Gleason felt it would be funnier without them.

Doug and Carrie heffernan

Wilbur and Carol Post (on "Mister Ed")
Brad and Joan Stephens ("I Married Joan")
Luke and Kate McCoy ("The Real McCoys")

George and Marion Kirby on "Topper"
Cosmo and Henrieta on "Topper"

Oliver and Lisa Douglas from "Green Acres"

Dharma and Greg Montgomery

Abner and Alice Kravitz

Pickles and Buddy Sorrell

Joe and Helen Hackett

Carol and Mike Brady...they didn't have children together...they adopted each other's children.

Robert and Amy Barone - Everybody Loves Raymond
Denise and Martin Kendall - The Cosby Show (stepdaughter)
Latka and Simka Gravas - Taxi
Norm and Vera Peterson - Cheers

Joe Hackett/Helen Chappel - Even though they were only married the last two seasons, they still count, hehe.

Martin and Gina (Martin)

Mark and Barbara Royer -One day at a time
Sam Royer & Ann Romano - One day at a time